Data/hora: 19/05/2024 16:21:12

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	11[beta]-hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17[beta]-hydroxysteroid dehydrogenase-type 2	
Autores: 	Michael E. Baker.	
Data: 	2010-07-10	
Ano: 	2010	
Palavras-chave: 	Cancer; Developmental Biology; Pharmacology; Bioinformatics; Evolutionary Biology.	
Resumo: 	11[beta]-hydroxysteroid dehydrogenase type-2 (11[beta]-HSD2) regulates the local concentration of cortisol that can activate the glucocorticoid receptor and mineralocorticoid receptor, as well as the concentration of 11-keto-testosterone, the active androgen in fish.  Similarly, 17[beta]-HSD2 regulates the levels of testosterone and estradiol that activate the androgen receptor and estrogen receptor, respectively.  Interestingly, although human 11[beta]-HSD2 and 17[beta]-HSD2 act at different positions on different steroids, these enzymes are paralogs.  Despite the physiological importance of 11[beta]-HSD2 and 17[beta]-HSD2, details of their origins and divergence from a common ancestor are not known.  An opportunity to understand their evolution is presented by the recent sequencing of genomes from sea urchin, a basal deuterostome, and amphioxus, a basal chordate, and the availability of substantial sequence for acorn worm and elephant shark, which together provide a more complete dataset for analysis of the origins of 11[beta]-HSD2 and 17[beta]-HSD2.  BLAST searches find an ancestral sequence of 17[beta]-HSD2 in sea urchin, acorn worm and amphioxus, while an ancestral sequence of 11[beta]-HSD2 first appears in sharks.  Sequence analyses indicate that 17[beta]-HSD2 in sea urchin may have a non-enzymatic activity.  Evolutionary analyses indicate that if acorn worm 17[beta]-HSD2 is catalytically active, then it metabolizes novel substrate(s).	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/4649/version/1

oai:nature.com:10.1038/npre.2010.4649.1

http://dx.doi.org/10.1038/npre.2010.4649.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License